Guanine base stacking in G-quadruplex nucleic acids
نویسندگان
چکیده
منابع مشابه
Guanine base stacking in G-quadruplex nucleic acids
G-quadruplexes constitute a class of nucleic acid structures defined by stacked guanine tetrads (or G-tetrads) with guanine bases from neighboring tetrads stacking with one another within the G-tetrad core. Individual G-quadruplexes can also stack with one another at their G-tetrad interface leading to higher-order structures as observed in telomeric repeat-containing DNA and RNA. In this study...
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1 IRB Barcelona, IQAC-CSIC, Jordi Girona 16-26, 08034 Barcelona, Spain 2 2 INSERM U869, Laboratoire ARNA, Université de Bordeaux 2, Institut Européen de Chimie-Biologie, 2 rue Robert Escarpit, 33607 Pessac Cedex, France 3Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II”, I-80126 Naples, Italy 4 Faculty of Mechanical Engineering, University of Maribor,...
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In building and refining nucleic acid structures, it is often desirable to enforce particular base pairing and/or base stacking interactions. Energy-based modeling programs with classical molecular mechanics force fields do not lend themselves to the easy imposition of penalty terms corresponding to such restraints, because the requirement that two bases lie in or near the same plane (pairing) ...
متن کاملIn What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?
Synthetic analogs of natural nucleotides have long been utilized for structural studies of canonical and noncanonical nucleic acids, including the extensively investigated polymorphic G-quadruplexes (GQs). Dependence on the sequence and nucleotide modifications of the folding landscape of GQs has been reviewed by several recent studies. Here, an overview is compiled on the thermodynamic stabili...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2012
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gks1110